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Nano scale Secondary Ion Mass Spectroscopy
Types of Techniques
- Liquid Chromatography Mass Spectrometry (LC-MS)
- Gas Chromatography-Mass Spectrometry (GC-MS)
- High-Performance Liquid Chromatography (HPLC)
- Inductively Coupled Plasma Mass Spectrometry (ICP-MS)
- Combustion Ion Chromatography (CIC)
- Ion Chromatography
- Gel Permeation Chromatography (GPC) / Size Exclusion Chromatography (SEC)
- Multi-Column Chromatography (MCC)
- LC-Orbitrap
- Accelerator Mass Spectrometry (AMS)
- Nano scale Secondary Ion Mass Spectroscopy
- Secondary-ion mass spectrometry (SIMS)
- SEC-MALS
Nano scale Secondary Ion Mass Spectroscopy
Nanoscale Secondary Ion Mass Spectrometry (NanoSIMS) is an advanced analytical technique used for high-resolution imaging and elemental analysis of surfaces, particularly at the nanoscale level.
NanoSIMS combines secondary ion mass spectrometry with high spatial resolution imaging capabilities, enabling the detection and quantification of elements and isotopes with exceptional sensitivity. It involves bombarding a sample surface with a primary ion beam (typically Cs⁺ or O⁻), which sputters secondary ions from the surface. These secondary ions are then analyzed by a mass spectrometer to determine their mass-to-charge ratios and thus identify the elemental and isotopic composition of the sample.
- Geosciences: Studying mineral compositions, meteorite analysis, and isotopic dating.
- Biology and Life Sciences: Investigating biological samples, such as cell structures and metabolic pathways.
- Materials Science: Analyzing semiconductor materials, thin films, and nanomaterials for elemental composition and structure.
- Environmental Science: Assessing pollution sources and elemental cycles in environmental samples.
- Depth Profiling: Provides depth profiling capabilities to analyze layered structures.
- Isotopic Resolution: Differentiates between isotopes of elements, crucial for understanding processes like diffusion and fractionation.
- Non-Destructive Imaging: Enables imaging and analysis of delicate samples without altering their structure.
Samples should fit within the size constraints of the NanoSIMS instrument’s sample stage, typically a few millimeters in diameter.