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Ion chromatography
Types of Techniques
- Liquid Chromatography Mass Spectrometry (LC-MS)
- Gas Chromatography-Mass Spectrometry (GC-MS)
- High-Performance Liquid Chromatography (HPLC)
- Inductively Coupled Plasma Mass Spectrometry (ICP-MS)
- Combustion Ion Chromatography (CIC)
- Ion Chromatography
- Gel Permeation Chromatography (GPC) / Size Exclusion Chromatography (SEC)
- Multi-Column Chromatography (MCC)
- LC-Orbitrap
- Accelerator Mass Spectrometry (AMS)
- Nano scale Secondary Ion Mass Spectroscopy
- Secondary-ion mass spectrometry (SIMS)
- SEC-MALS
Ion chromatography
Ion chromatography (IC) is an analytical technique used for the separation and quantification of ionic compounds. It is particularly useful for analyzing anions, cations, and other polar molecules in various sample matrices. IC employs an ion-exchange resin as the stationary phase and an aqueous buffer solution as the mobile phase. Analytes are separated based on their ionic interactions with the stationary phase and are detected by conductivity or other detectors, allowing for both qualitative and quantitative analysis.
The working principle of ion chromatography is based on the selective separation of ions using an ion-exchange process. The sample is injected into a stream of an aqueous mobile phase, which carries the ions through an analytical column packed with a solid stationary phase. The stationary phase consists of an ion-exchange resin with charged functional groups that interact with the ions in the sample. Depending on their affinity for the stationary phase, different ions are retained for varying amounts of time, leading to their separation. The separated ions are then detected by a conductivity detector or other detectors, allowing for their identification and quantification based on their retention times and peak areas.
- Analysis of surface treatments and coatings on aerospace components
- Characterization of alloys and composite materials
- Determination of ionic contaminants in aerospace fluids
- Analysis of coolants and antifreeze solutions
- Characterization of surface coatings and platings
- Determination of ionic species in automotive lubricants
- Analysis of industrial chemicals and process streams
- Characterization of catalysts and adsorbents
- Determination of ionic impurities in chemical products
- Analysis of ionic contaminants in electronic components
- Characterization of plating solutions and surface treatments
- Determination of ionic species in display materials
- Analysis of propellants and explosive materials
- Characterization of protective coatings and surface treatments
- Determination of ionic species in military materials
- Analysis of ionic species in battery electrolytes
- Characterization of fuel cell components
- Determination of ionic contaminants in energy generation systems
- Analysis of forensic evidence for ionic species
- Characterization of counterfeit products
- Determination of ionic contaminants in product failure investigations
- Analysis of phosphor materials and coatings
- Characterization of ionic species in lighting components
- Determination of ionic contaminants in LED devices
- Analysis of implant materials and coatings
- Characterization of drug delivery systems
- Determination of ionic species in medical instrumentation
- Analysis of active pharmaceutical ingredients (APIs)
- Characterization of excipients and formulations
- Determination of ionic impurities in pharmaceutical products
- Analysis of ionic species in raw materials
- Characterization of mineral and ore samples
- Determination of ionic contaminants in construction materials
- Analysis of ionic contaminants in semiconductor materials
- Characterization of plating solutions and surface treatments
- Determination of ionic species in microelectronic components
- Analysis of ionic contaminants in telecommunication components
- Characterization of materials used in data storage devices
- Determination of ionic species in fiber optic cables
- Simultaneous analysis of multiple ionic species
- High sensitivity and low detection limits
- Excellent resolution and separation efficiency
- Versatility in handling various sample matrices
- Rapid analysis times
- Ability to analyze both inorganic and organic ions
- Sample Quantity: Typically, a few milliliters (1-5 mL) of sample solution is sufficient for analysis.
- Sample Preparation: The sample should be in a liquid or dissolved state, and any particulates or insoluble materials should be removed by filtration or centrifugation.
- Sample Volume: The minimum injection volume can range from a few microliters to hundreds of microliters, depending on the instrument specifications.