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Inductively Coupled Plasma Mass Spectrometry
Types of Techniques
- Liquid Chromatography Mass Spectrometry (LC-MS)
- Gas Chromatography-Mass Spectrometry (GC-MS)
- High-Performance Liquid Chromatography (HPLC)
- Inductively Coupled Plasma Mass Spectrometry (ICP-MS)
- Combustion Ion Chromatography (CIC)
- Ion Chromatography
- Gel Permeation Chromatography (GPC) / Size Exclusion Chromatography (SEC)
- Multi-Column Chromatography (MCC)
- LC-Orbitrap
- Accelerator Mass Spectrometry (AMS)
- Nano scale Secondary Ion Mass Spectroscopy
- Secondary-ion mass spectrometry (SIMS)
- SEC-MALS
Inductively Coupled Plasma Mass Spectrometry (ICP-MS)
ICP-MS is a highly sensitive technique, to determine the ultra-trace elements present in the sample. This technique can study the trace elemental concentration of solid, liquid and gaseous samples. The combination of the induced coupled plasma and Mass spectrometer was employed to perform the trace elemental analysis. The Inductively coupled plasma produces the charged ions from the sample using the argon plasma. Then the charged ions pass through the mass spectrometer, where it separated based on its ions to mass ratio. Subsequently, the ions have been detected using the mass spectrometer detector and the intensity of the ions was used to determine the elemental composition present in the sample. This analysis has the ability to identify and quantitate elements down to the sub-parts-per-billion range. Further, a wide range of materials from super alloys to high-purity materials can be analyzed using this 46 technique.
In ICP-MS, the chemical compounds in the samples are broken down to their atomic ions using high-temperature plasma. Following that, the ions are found and measured using mass spectrometry in order to differentiate between various elements and occasionally, their isotopes based on their mass-to-charge ratio. Lighter ions experience a stronger force under the same electrical and magnetic fields, resulting in distinct trajectories. Finally, a detector counts the ions for each m/z value, allowing identification based on known isotopic masses. This powerful combination enables ICP-MS to achieve ultra-low detection limits and even differentiate between isotopes of the same element.
- Ultra-trace analysis of heavy metals in soil, water, and air samples
- Isotopic fingerprinting of pollutants for source identification
- Studying the fate and transport of metal contaminants in the environment
- Ultra-low detection of trace elements impacting device performance
- Isotopic analysis of dopant materials for purity and process control
- Characterization of ultra-thin film composition
- Detecting and quantifying trace elements like arsenic, mercury, and lead at ultra-low levels
- Analyzing the isotopic composition of food sources for geographical authentication
- Studying the uptake and distribution of elements in food crops
- Quantifying metal impurities in drug formulations at part-per-trillion levels
- Isotopic analysis of drug components for authenticity and quality control
- Studying the biocompatibility of metal-based implants and drug delivery systems
- Precise determination of elemental abundances and isotopic ratios in rocks, minerals, and meteorites
- Dating geological formations using radioisotopes
- Understanding the origin and evolution of the Earth and other celestial bodies
- Trace element analysis in hair, blood, and other samples to link suspects to crime scenes
- Isotopic analysis of materials for geographical origin determination
- Identifying gunshot residue composition through elemental fingerprinting
- Ultra-trace analysis of contaminants in fuels and lubricants
- Isotopic analysis of crude oil for source identification
- Studying the behaviour of trace elements during fuel combustion and refining processes
- Analyzing the elemental composition of plant tissues for nutrient deficiencies
- Isotopic analysis of fertilizers to determine their source and effectiveness
- Studying the interaction of trace elements with plant growth and development
- Characterization of advanced materials for elemental composition and impurities
- Isotopic analysis of raw materials for traceability and quality control
- Investigating the degradation mechanisms of materials through elemental profiling
- Studying the role of trace elements in biological processes at ultratrace levels
- Isotopic analysis of biomolecules for metabolic studies
- Investigating the interaction of metal-based drugs with tissues and organs
- a) High Sensitivity
- b) Multi-Element Capability
- c) Isotopic Analysis
- d) Flexibility
- Solid Sample – 5 gm.
- Liquid Sample – 5 ml.
- Raw materials
- Waste
- Drinking and process water
- Impurities in drugs and pharmaceuticals
- Biomass
- Environmental measurements
- Mining, rocks and minerals
- Catalysts
- Isotope studies
- Organic polymers
- Food and beverages
- Semiconductor materials