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CHALLENGE:
Advanced drug delivery systems, faced a critical challenge in determining the localization of API within their microparticles. The effectiveness of their drug delivery systems relied on knowing whether API were encapsulated within the microparticles or present on their surface. This information is crucial for ensuring the intended release profiles and efficacy of the drugs.
SOLUTION:
To detect the specific Raman peaks associated with the API interest. Raman mapping was performed to obtain spatially resolved spectra from different areas of the microparticles. This process involved scanning the surface and cross-sections to create detailed maps of API distribution.
- Distribution of components in the drug
- Characterization of Drug-Excipient Interactions
Red peak indicates the AIP, Blue peak indicates the Excipient &Green peak indicates the polymer matrix.
Dark filed image of Finished Product using 20 magnification objective lens.
➢ Red sphere indicates the presence of API
➢ Blue spot indicates the presence of excipient
➢ Green spot indicates the polymer matrix
RESULT:
What We Attain
➢ API Drug is identified in the finished product.
➢ API distribution in the finished product & microspheres.
➢ API interaction in the microsphere.
➢ Identification of API drug over the microsphere as well as inside the microsphere. ➢ Efficiency in Processing
Insight obtained from the study
➢ Microparticle Interaction
➢ Quality Control
➢ Bioavailability Considerations
➢ Improved Efficiency
➢ Efficiency in Processing
➢ Regulatory Compliance
The outcomes of this project provide crucial support to our customer in achieving physicochemical and structural characteristic of API with microparticle in the drug.
Additionally, these results contribute to efficient quality control, formulation optimization, regulatory compliance, and process enhancement in the drug.